Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulon of PurR in Lactobacillus rhamnosus GG

Properties
Regulator type: Transcription factor
TF locus tag: LGG_02564
Regulator family: PurR
Regulation mode: repressor
Biological process: Purine metabolism
Effector: 5-phosphoribosyl 1-pyrophosphate
Regulog: PurR - Lactobacillaceae
Statistics of regulated genes:
- Genes 16
- Operons 5
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 76 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -194
Score: 5.3
Sequence: AAAGACGAACATT
Locus tag: LGG_00249
Name: guaB
Funciton: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)
guaB
Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)

Position: -134
Score: 5.6
Sequence: AAACACGAACATT
Locus tag: LGG_00874
Name: guaC
Funciton: GMP reductase (EC 1.7.1.7)
guaC
GMP reductase (EC 1.7.1.7)

Position: -108
Score: 5.5
Sequence: AAATACGAACATT
Position: -96
Score: 4.3
Sequence: TAAAACGAATAAT
Locus tag: LGG_01814
Name: purE
Funciton: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)
Locus tag: LGG_01813
Name: purK
Funciton: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)
Locus tag: LGG_01812
Name: purC
Funciton: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)
Locus tag: LGG_01811
Name: purS
Funciton: Phosphoribosylformylglycinamidine synthase, PurS subunit (EC 6.3.5.3)
Locus tag: LGG_01810
Name: purQ
Funciton: Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)
Locus tag: LGG_01809
Name: purL
Funciton: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3)
Locus tag: LGG_01808
Name: purF
Funciton: Amidophosphoribosyltransferase (EC 2.4.2.14)
Locus tag: LGG_01807
Name: purM
Funciton: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)
Locus tag: LGG_01806
Name: purN
Funciton: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)
Locus tag: LGG_01805
Name: purH
Funciton: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)
Locus tag: LGG_01804
Name: LGG_02640
Funciton: Hypothetical protein
Locus tag: LGG_01803
Name: purD
Funciton: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)
purS
Phosphoribosylformylglycinamidine synthase, PurS subunit (EC 6.3.5.3)
purQ
Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)
purL
Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3)
purF
Amidophosphoribosyltransferase (EC 2.4.2.14)
purM
Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)
purN
Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)
purH
IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)
LGG_02640
Hypothetical protein
purD
Phosphoribosylamine--glycine ligase (EC 6.3.4.13)

Position: -105
Score: 5.6
Sequence: AAACACGAACATT
Locus tag: LGG_00168
Name: pbuO
Funciton: Guanine/hypoxanthine permease
pbuO
Guanine/hypoxanthine permease

Position: -126
Score: 4.8
Sequence: AAATGCGAACGTT
Locus tag: LGG_02564
Name: purR
Funciton: Purine metabolism transcriptional regulator PurR, PurR family
purR
Purine metabolism transcriptional regulator PurR, PurR family
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