Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulon of PurR in Lactobacillus acidophilus NCFM

Properties
Regulator type: Transcription factor
TF locus tag: LBA0218
Regulator family: PurR
Regulation mode: repressor
Biological process: Purine metabolism
Effector: 5-phosphoribosyl 1-pyrophosphate
Regulog: PurR - Lactobacillaceae
Statistics of regulated genes:
- Genes 19
- Operons 7
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 76 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -120
Score: 4.4
Sequence: AAAACCGAATTAT
Locus tag: LBA1893
Name: guaC
Funciton: GMP reductase (EC 1.7.1.7)
guaC
GMP reductase (EC 1.7.1.7)

Position: -151
Score: 5.3
Sequence: AAACACGAACGAT
Locus tag: LBA1559
Name: purC
Funciton: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)
Locus tag: LBA1558
Name: purS
Funciton: Phosphoribosylformylglycinamidine synthase, PurS subunit (EC 6.3.5.3)
Locus tag: LBA1557
Name: purQ
Funciton: Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)
Locus tag: LBA1556
Name: purL
Funciton: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3)
Locus tag: LBA1555
Name: purF
Funciton: Amidophosphoribosyltransferase (EC 2.4.2.14)
Locus tag: LBA1554
Name: purM
Funciton: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)
Locus tag: LBA1553
Name: purN
Funciton: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)
Locus tag: LBA1552
Name: purH
Funciton: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)
Locus tag: LBA1551
Name: purD
Funciton: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)
purS
Phosphoribosylformylglycinamidine synthase, PurS subunit (EC 6.3.5.3)
purQ
Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)
purL
Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3)
purF
Amidophosphoribosyltransferase (EC 2.4.2.14)
purM
Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)
purN
Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)
purH
IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)
purD
Phosphoribosylamine--glycine ligase (EC 6.3.4.13)

Position: -59
Score: 4.4
Sequence: ATATAAGAACAAT
Locus tag: LBA1562
Name: fhs
Funciton: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
Locus tag: LBA1561
Name: purE
Funciton: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)
Locus tag: LBA1560
Name: purK
Funciton: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)
fhs
Formate--tetrahydrofolate ligase (EC 6.3.4.3)
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)

Position: -123
Score: 4.9
Sequence: AAAATCGAACTAT
Locus tag: LBA1892
Name: purA
Funciton: Adenylosuccinate synthetase (EC 6.3.4.4)
Locus tag: LBA1891
Name: purB
Funciton: Adenylosuccinate lyase (EC 4.3.2.2)
purA
Adenylosuccinate synthetase (EC 6.3.4.4)
purB
Adenylosuccinate lyase (EC 4.3.2.2)

Position: 29
Score: 4.4
Sequence: AAAGGAGAACAAT
Locus tag: LBA1956
Name: pbuO
Funciton: Guanine/hypoxanthine permease
pbuO
Guanine/hypoxanthine permease

Position: -27
Score: 4.8
Sequence: AAAACCAAACATT
Locus tag: LBA0218
Name: purR
Funciton: Purine metabolism transcriptional regulator PurR, PurR family
Locus tag: LBA0219
Name: glmU
Funciton: N-acetylglucosamine-1-phosphate uridyltransferase (EC 2.7.7.23) / Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)
purR
Purine metabolism transcriptional regulator PurR, PurR family
glmU
N-acetylglucosamine-1-phosphate uridyltransferase (EC 2.7.7.23) / Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)

Position: -30
Score: 5.6
Sequence: AAACACGAACAAT
Locus tag: LBA1952
Name: pbuO
Funciton: Guanine/hypoxanthine permease
pbuO
Guanine/hypoxanthine permease
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