Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulon of CcpA in Lactobacillus salivarius subsp. salivarius UCC118

Properties
Regulator type: Transcription factor
TF locus tag: LSL_0420
Regulator family: LacI
Regulation mode:
Biological process: Carbon catabolism
Effector: HPr, phosphocarrier protein; Fructose-1,6-bisphosphate
Regulog: CcpA - Lactobacillaceae
Statistics of regulated genes:
- Genes 81
- Operons 33
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 561 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -71
Score: 4.2
Sequence: TTGTAAGCATTTACGA
Locus tag: LSL_0560
Name: manO
Funciton: Predicted regulator of the mannose operon, ManO
manO
Predicted regulator of the mannose operon, ManO

Position: -88
Score: 4
Sequence: GTGAAAGCTATTTCTT
Locus tag: LSL_1294
Name: glgB
Funciton: 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18)
Locus tag: LSL_1293
Name: glgC
Funciton: Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27)
Locus tag: LSL_1292
Name: glgD
Funciton: Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27)
Locus tag: LSL_1291
Name: glgA
Funciton: Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21)
Locus tag: LSL_1290
Name: glgP
Funciton: Glycogen phosphorylase (EC 2.4.1.1)
Locus tag: LSL_1289
Name: amy1
Funciton: Neopullulanase (EC 3.2.1.135)
glgB
1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18)
glgC
Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27)
glgD
Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27)
glgA
Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21)
glgP
Glycogen phosphorylase (EC 2.4.1.1)
amy1
Neopullulanase (EC 3.2.1.135)

Position: -75
Score: 4.2
Sequence: TTGAAAGCGTAATATT
Locus tag: LSL_1538
Name: coaA
Funciton: Pantothenate kinase (EC 2.7.1.33)
Locus tag: LSL_1537
Name: guaA
Funciton: GMP synthase (EC 6.3.5.2)
coaA
Pantothenate kinase (EC 2.7.1.33)
guaA
GMP synthase (EC 6.3.5.2)

Position: -149
Score: 4.4
Sequence: GAATAAGCGTTTTCAT
Position: -43
Score: 4.8
Sequence: AAGAAAACGTTTTCTT
Locus tag: LSL_0110
Name: glpK
Funciton: Glycerol kinase (EC 2.7.1.30)
Locus tag: LSL_0111
Name: glpD
Funciton: Alpha-glycerophosphate oxidase (EC 1.1.3.21)
Locus tag: LSL_0112
Name: glpF
Funciton: Glycerol uptake facilitator protein
glpK
Glycerol kinase (EC 2.7.1.30)
glpD
Alpha-glycerophosphate oxidase (EC 1.1.3.21)
glpF
Glycerol uptake facilitator protein

Position: -18
Score: 4.1
Sequence: TTGAAAGGGGTATAAT
Locus tag: LSL_1806
Name: rpiA
Funciton: Ribose 5-phosphate isomerase A (EC 5.3.1.6)
Locus tag: LSL_1807
Name: rpe
Funciton: Ribulose-phosphate 3-epimerase (EC 5.1.3.1)
rpiA
Ribose 5-phosphate isomerase A (EC 5.3.1.6)
rpe
Ribulose-phosphate 3-epimerase (EC 5.1.3.1)

Position: -76
Score: 4.3
Sequence: AAGGAAGCGGTAACAA
Locus tag: LSL_1296
Name: LSL_1296
Funciton: Hypothetical protein
Locus tag: LSL_1295
Name: nplT
Funciton: Neopullulanase (EC 3.2.1.135)
LSL_1296
Hypothetical protein
nplT
Neopullulanase (EC 3.2.1.135)

Position: -109
Score: 4.3
Sequence: TAGAAATCGTTTACAC
Locus tag: LSL_0086
Name: manL
Funciton: Mannose-specific PTS system, IIAB component (EC 2.7.1.69)
Locus tag: LSL_0087
Name: manM
Funciton: Mannose-specific PTS system, IIC component (EC 2.7.1.69)
Locus tag: LSL_0088
Name: manN
Funciton: Mannose-specific PTS system, IID component (EC 2.7.1.69)
Locus tag: LSL_0089
Name: manO
Funciton: Predicted regulator of the mannose operon, ManO
manL
Mannose-specific PTS system, IIAB component (EC 2.7.1.69)
manM
Mannose-specific PTS system, IIC component (EC 2.7.1.69)
manN
Mannose-specific PTS system, IID component (EC 2.7.1.69)
manO
Predicted regulator of the mannose operon, ManO

Position: -131
Score: 4.3
Sequence: TAGTAAGTGTTTTCAA
Position: -61
Score: 4.1
Sequence: ATGAAAAGGCTTTATT
Locus tag: LSL_0654
Name: manL
Funciton: Mannose-specific PTS system, IIAB component (EC 2.7.1.69)
Locus tag: LSL_0655
Name: manM
Funciton: Mannose-specific PTS system, IIC component (EC 2.7.1.69)
Locus tag: LSL_0656
Name: manN
Funciton: Mannose-specific PTS system, IID component (EC 2.7.1.69)
manL
Mannose-specific PTS system, IIAB component (EC 2.7.1.69)
manM
Mannose-specific PTS system, IIC component (EC 2.7.1.69)
manN
Mannose-specific PTS system, IID component (EC 2.7.1.69)

Position: -53
Score: 4.6
Sequence: AAGAAAACGTTTGCAA
Locus tag: LSL_1372
Name: spxB
Funciton: Pyruvate oxidase (EC 1.2.3.3)
spxB
Pyruvate oxidase (EC 1.2.3.3)

Position: -181
Score: 4.2
Sequence: ATGTAAGCGTTATTCT
Locus tag: LSL_1881
Name: sufC
Funciton: Iron-sulfur cluster assembly ATPase protein
Locus tag: LSL_1880
Name: sufD
Funciton: Iron-sulfur cluster assembly protein
Locus tag: LSL_1879
Name: sufS
Funciton: Cysteine desulfurase (EC 2.8.1.7), SufS subfamily
Locus tag: LSL_1878
Name: sufA
Funciton: Fe-S cluster formation protein, NifU-like
Locus tag: LSL_1877
Name: sufB
Funciton: Fe-S cluster assembly ABC-type transport system, permease component
sufC
Iron-sulfur cluster assembly ATPase protein
sufD
Iron-sulfur cluster assembly protein
sufS
Cysteine desulfurase (EC 2.8.1.7), SufS subfamily
sufA
Fe-S cluster formation protein, NifU-like
sufB
Fe-S cluster assembly ABC-type transport system, permease component

Position: -56
Score: 4.2
Sequence: CAGTAAACGTTATCAT
Locus tag: LSL_1620
Name: mtlA
Funciton: Mannitol-specific PTS system, IIBC component (EC 2.7.1.69)
Locus tag: LSL_1619
Name: mtlF
Funciton: Mannitol-specific PTS system, mannitol-specific IIA component (EC 2.7.1.69)
Locus tag: LSL_1618
Name: mtlD
Funciton: Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)
mtlA
Mannitol-specific PTS system, IIBC component (EC 2.7.1.69)
mtlF
Mannitol-specific PTS system, mannitol-specific IIA component (EC 2.7.1.69)
mtlD
Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)

Position: -73
Score: 4.6
Sequence: TTGAAAACGGTTAATA
Locus tag: LSL_1751
Name: rhaY
Funciton: Predicted L-rhamnose permease RhaY
Locus tag: LSL_1752
Name: rhaB
Funciton: Rhamnulokinase (EC 2.7.1.5)
Locus tag: LSL_1753
Name: rhaU
Funciton: L-rhamnose 1-epimerase (EC 5.1.3.-)
Locus tag: LSL_1754
Name: rhaA
Funciton: L-rhamnose isomerase (EC 5.3.1.14)
Locus tag: LSL_1755
Name: rhaD
Funciton: Rhamnulose-1-phosphate aldolase (EC 4.1.2.19)
rhaY
Predicted L-rhamnose permease RhaY
rhaB
Rhamnulokinase (EC 2.7.1.5)
rhaU
L-rhamnose 1-epimerase (EC 5.1.3.-)
rhaA
L-rhamnose isomerase (EC 5.3.1.14)
rhaD
Rhamnulose-1-phosphate aldolase (EC 4.1.2.19)

Position: -39
Score: 4.2
Sequence: TTGAAAGTGTATACAT
Locus tag: LSL_1613
Name: pmi
Funciton: Mannose-6-phosphate isomerase (EC 5.3.1.8)
pmi
Mannose-6-phosphate isomerase (EC 5.3.1.8)

Position: -96
Score: 4.5
Sequence: TTGTAAACAATTTCAT
Position: -27
Score: 4.1
Sequence: AAGAAAAGGTTTTCAG
Locus tag: LSL_1512
Name: treP
Funciton: Trehalose-specific PTS system, EIIABC component (EC 2.7.1.69)
treP
Trehalose-specific PTS system, EIIABC component (EC 2.7.1.69)

Position: -130
Score: 4.2
Sequence: ATGAAATTGTTTACAA
Locus tag: LSL_1513
Name: treR
Funciton: Trehalose utilization transcriptional regulator TreR, GntR family
Locus tag: LSL_1514
Name: treA
Funciton: Trehalose-6-phosphate hydrolase (EC 3.2.1.93)
treR
Trehalose utilization transcriptional regulator TreR, GntR family
treA
Trehalose-6-phosphate hydrolase (EC 3.2.1.93)

Position: -46
Score: 4.4
Sequence: ATGAAAGCGTATTATA
Locus tag: LSL_0395
Name: pck
Funciton: Phosphoenolpyruvate carboxykinase (EC 4.1.1.49)
pck
Phosphoenolpyruvate carboxykinase (EC 4.1.1.49)

Position: -69
Score: 4.5
Sequence: ATGAAAGCGAATTTAA
Locus tag: LSL_1117
Name: lulA
Funciton: Lactate utilization protein A
Locus tag: LSL_1116
Name: lulC
Funciton: Lactate utilization protein C
Locus tag: LSL_1115
Name: lulB
Funciton: Lactate utilization protein B
lulA
Lactate utilization protein A
lulC
Lactate utilization protein C
lulB
Lactate utilization protein B

Position: -31
Score: 4.4
Sequence: TTGTAAACGATGTCAA
Locus tag: LSL_1748
Name: adhX
Funciton: Zn conatining alcohol dehydrogenase
adhX
Zn conatining alcohol dehydrogenase

Position: -37
Score: 4.3
Sequence: ATGTAAGCGTACTCAA
Locus tag: LSL_1298
Name: gabD
Funciton: Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16)
gabD
Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16)

Position: -125
Score: 4
Sequence: TTGCAAGCGTTTCATA
Locus tag: LSL_0419
Name: pepQ
Funciton: Xaa-Pro dipeptidase (EC 3.4.13.9)
pepQ
Xaa-Pro dipeptidase (EC 3.4.13.9)

Position: -91
Score: 4.1
Sequence: TTGTTATCGTTTGCAT
Position: -68
Score: 4.2
Sequence: ATGTAAACGTGTTCTT
Locus tag: LSL_0388
Name: ptsH
Funciton: Phosphotransferase system, HPr-related protein
Locus tag: LSL_0389
Name: ptsI
Funciton: Phosphoenolpyruvate-protein kinase, PTS system component (EC 2.7.3.9)
ptsH
Phosphotransferase system, HPr-related protein
ptsI
Phosphoenolpyruvate-protein kinase, PTS system component (EC 2.7.3.9)

Position: -121
Score: 4.1
Sequence: ATTTAACCGCTTTTTT
Position: -33
Score: 4.5
Sequence: AAGAATACGTTTACAA
Locus tag: LSL_0065
Name: scrB
Funciton: Sucrose-6-phosphate hydrolase (EC 3.2.1.26)
Locus tag: LSL_0064
Name: scrR
Funciton: Sucrose operon repressor ScrR, LacI family
scrB
Sucrose-6-phosphate hydrolase (EC 3.2.1.26)
scrR
Sucrose operon repressor ScrR, LacI family

Position: -216
Score: 4
Sequence: GTGATAACGATAACAA
Position: -67
Score: 4.5
Sequence: TTGTAAGCGTTATATA
Locus tag: LSL_0153
Name: pdhA
Funciton: Dihydrolipoamide dehydrogenase complex (EC 1.8.1.4), E1 component alpha-subunit
Locus tag: LSL_0154
Name: pdhB
Funciton: Dihydrolipoamide dehydrogenase complex (EC 1.8.1.4), E1 component beta-subunit
Locus tag: LSL_0155
Name: pdhC
Funciton: Dihydrolipoamide dehydrogenase complex (EC 1.8.1.4), E2 component
Locus tag: LSL_0156
Name: pdhD
Funciton: Dihydrolipoamide dehydrogenase complex (EC 1.8.1.4), E3 component
Locus tag: LSL_0157
Name: lplA1
Funciton: Lipoate-protein ligase A
pdhA
Dihydrolipoamide dehydrogenase complex (EC 1.8.1.4), E1 component alpha-subunit
pdhB
Dihydrolipoamide dehydrogenase complex (EC 1.8.1.4), E1 component beta-subunit
pdhC
Dihydrolipoamide dehydrogenase complex (EC 1.8.1.4), E2 component
pdhD
Dihydrolipoamide dehydrogenase complex (EC 1.8.1.4), E3 component
lplA1
Lipoate-protein ligase A

Position: -52
Score: 4.2
Sequence: CATTAAGCGTTTTCAA
Locus tag: LSL_0066
Name: scrA
Funciton: Sucrose-specific PTS system, IIABC component (EC 2.7.1.69)
scrA
Sucrose-specific PTS system, IIABC component (EC 2.7.1.69)

Position: -150
Score: 4.9
Sequence: TTTAAAACGTTTTCAT
Position: -43
Score: 4.5
Sequence: GTGAAAACGATTACTA
Locus tag: LSL_0134
Name: ydgI
Funciton: Putative NAD(P)H nitroreductase
ydgI
Putative NAD(P)H nitroreductase

Position: -32
Score: 4.5
Sequence: ATGTAAGCATTTTCTT
Locus tag: LSL_0376
Name: lacLM
Funciton: Beta-galactosidase large subunit (EC 3.2.1.23) / Beta-galactosidase small subunit (EC 3.2.1.23)
lacLM
Beta-galactosidase large subunit (EC 3.2.1.23) / Beta-galactosidase small subunit (EC 3.2.1.23)

Position: -63
Score: 4.3
Sequence: TTGTAACCGTTAACAC
Locus tag: LSL_1894
Name: sorD
Funciton: Sorbitol-6-phosphate 2-dehydrogenase (EC 1.1.1.140)
Locus tag: LSL_1893
Name: srlM
Funciton: Sorbitol operon transcription regulator
Locus tag: LSL_1892
Name: srlR
Funciton: Glucitol operon activator protein
Locus tag: LSL_1891
Name: srlA
Funciton: Glucitol/sorbitol-specific PTS system, IIC component (EC 2.7.1.69)
Locus tag: LSL_1890
Name: srlE
Funciton: Glucitol/sorbitol-specific PTS system, IIBC components (EC 2.7.1.69)
Locus tag: LSL_1889
Name: srlB
Funciton: Glucitol/sorbitol-specific PTS system, IIA component (EC 2.7.1.69)
sorD
Sorbitol-6-phosphate 2-dehydrogenase (EC 1.1.1.140)
srlM
Sorbitol operon transcription regulator
srlR
Glucitol operon activator protein
srlA
Glucitol/sorbitol-specific PTS system, IIC component (EC 2.7.1.69)
srlE
Glucitol/sorbitol-specific PTS system, IIBC components (EC 2.7.1.69)
srlB
Glucitol/sorbitol-specific PTS system, IIA component (EC 2.7.1.69)

Position: -200
Score: 4.3
Sequence: TTGACACCGCTTACAG
Locus tag: LSL_1300
Name: lp_0827
Funciton: Conserved hypothetical protein
lp_0827
Conserved hypothetical protein

Position: -59
Score: 4.5
Sequence: AAGAATGCGATTTCAT
Locus tag: LSL_1282
Name: malT
Funciton: Predicted maltose/maltodextrin permease
Locus tag: LSL_1281
Name: galM
Funciton: Aldose 1-epimerase
Locus tag: LSL_1280
Name: mapA
Funciton: Maltose phosphorylase (EC 2.4.1.8) / Trehalose phosphorylase (EC 2.4.1.64)
Locus tag: LSL_1279
Name: pgmB
Funciton: Beta-phosphoglucomutase (EC 5.4.2.6)
malT
Predicted maltose/maltodextrin permease
galM
Aldose 1-epimerase
mapA
Maltose phosphorylase (EC 2.4.1.8) / Trehalose phosphorylase (EC 2.4.1.64)
pgmB
Beta-phosphoglucomutase (EC 5.4.2.6)

Position: -140
Score: 4.3
Sequence: TAGTAATCGTTTTCAC
Position: -33
Score: 5
Sequence: ATGAAAACGTTTTAAA
Locus tag: LSL_0135
Name: adc
Funciton: Probable acetoacetate decarboxylase
Locus tag: LSL_0136
Name: mmgB
Funciton: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)
adc
Probable acetoacetate decarboxylase
mmgB
3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)

Position: -56
Score: 3.8
Sequence: GTGAAAACGTTCTATA
Locus tag: LSL_0137
Name: hcaD
Funciton: NADH peroxidase (EC 1.11.1.1)
hcaD
NADH peroxidase (EC 1.11.1.1)

Position: -64
Score: 5
Sequence: TTGAAAGCGTTTATAT
Locus tag: LSL_1633
Name: dhaK
Funciton: Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), dihydroxyacetone binding subunit DhaK
Locus tag: LSL_1632
Name: dhaL
Funciton: Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), ADP-binding subunit DhaL
Locus tag: LSL_1631
Name: dhaM
Funciton: Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), subunit DhaM; DHA-specific IIA component
Locus tag: LSL_1630
Name: glpF2
Funciton: Glycerol uptake facilitator protein
dhaK
Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), dihydroxyacetone binding subunit DhaK
dhaL
Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), ADP-binding subunit DhaL
dhaM
Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), subunit DhaM; DHA-specific IIA component
glpF2
Glycerol uptake facilitator protein

Position: -44
Score: 4.3
Sequence: AATAAAACGTTTTCTT
Locus tag: LSL_0381
Name: galK
Funciton: Galactokinase (EC 2.7.1.6)
Locus tag: LSL_0382
Name: galE
Funciton: UDP-glucose 4-epimerase (EC 5.1.3.2)
Locus tag: LSL_0383
Name: galT
Funciton: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
galK
Galactokinase (EC 2.7.1.6)
galE
UDP-glucose 4-epimerase (EC 5.1.3.2)
galT
Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
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