Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulon of CcpA in Lactobacillus acidophilus NCFM

Properties
Regulator type: Transcription factor
TF locus tag: LBA0431
Regulator family: LacI
Regulation mode:
Biological process: Carbon catabolism
Effector: HPr, phosphocarrier protein; Fructose-1,6-bisphosphate
Regulog: CcpA - Lactobacillaceae
Statistics of regulated genes:
- Genes 70
- Operons 37
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 561 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -75
Score: 4.4
Sequence: CTGTAAACGTTTGCAA
Locus tag: LBA0431
Name: ccpA
Funciton: Carbon catabolism global transcriptional regulator CcpA, LacI family
ccpA
Carbon catabolism global transcriptional regulator CcpA, LacI family

Position: -110
Score: 4.4
Sequence: GAAAAAGCGGTTTCAT
Position: -78
Score: 4
Sequence: AAGATAGCGTTTTGAA
Locus tag: LBA1974
Name: spxB
Funciton: Pyruvate oxidase (EC 1.2.3.3)
spxB
Pyruvate oxidase (EC 1.2.3.3)

Position: -61
Score: 4.1
Sequence: TTGGATGCGTTTTTTT
Locus tag: LBA0587
Name: rbsK
Funciton: Ribokinase (EC 2.7.1.15)
Locus tag: LBA0588
Name: rpiA
Funciton: Ribose 5-phosphate isomerase A (EC 5.3.1.6)
rbsK
Ribokinase (EC 2.7.1.15)
rpiA
Ribose 5-phosphate isomerase A (EC 5.3.1.6)

Position: -101
Score: 4.7
Sequence: TTGAAAGCGATTACAC
Locus tag: LBA1485
Name: rbsK
Funciton: Ribokinase (EC 2.7.1.15)
Locus tag: LBA1484
Name: rbsD
Funciton: Ribose ABC transport system, high affinity permease RbsD (TC 3.A.1.2.1)
Locus tag: LBA1483
Name: rbsA
Funciton: Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1)
Locus tag: LBA1482
Name: rbsC
Funciton: Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1)
Locus tag: LBA1481
Name: rbsB
Funciton: Ribose ABC transport system, periplasmic ribose-binding protein RbsB (TC 3.A.1.2.1)
rbsK
Ribokinase (EC 2.7.1.15)
rbsD
Ribose ABC transport system, high affinity permease RbsD (TC 3.A.1.2.1)
rbsA
Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1)
rbsC
Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1)
rbsB
Ribose ABC transport system, periplasmic ribose-binding protein RbsB (TC 3.A.1.2.1)

Position: -53
Score: 5.1
Sequence: ATGAAAGCGCTTAAAA
Locus tag: LBA1442
Name: msmE
Funciton: Multiple sugar ABC transporter, substrate-binding protein
Locus tag: LBA1441
Name: msmF
Funciton: Multiple sugar ABC transporter, permease protein 2
Locus tag: LBA1440
Name: msmG
Funciton: Multiple sugar ABC transporter, permease protein 1
msmE
Multiple sugar ABC transporter, substrate-binding protein
msmF
Multiple sugar ABC transporter, permease protein 2
msmG
Multiple sugar ABC transporter, permease protein 1

Position: -49
Score: 5
Sequence: TTGAAAACGGTTTCTT
Locus tag: LBA1872
Name: agl
Funciton: Oligo-1,6-glucosidase (EC 3.2.1.10)
Locus tag: LBA1871
Name: nplT
Funciton: Neopullulanase (EC 3.2.1.135)
agl
Oligo-1,6-glucosidase (EC 3.2.1.10)
nplT
Neopullulanase (EC 3.2.1.135)

Position: -205
Score: 3.8
Sequence: ATGAAACCAGTATTAT
Locus tag: LBA0271
Name: ldh
Funciton: L-lactate dehydrogenase (EC 1.1.1.27)
ldh
L-lactate dehydrogenase (EC 1.1.1.27)

Position: -196
Score: 4.3
Sequence: TTTAAAACATTTTCAT
Position: -163
Score: 4.8
Sequence: TTGACACCGCTTTCAA
Locus tag: LBA0724
Name: licT
Funciton: Beta-glucoside bgl operon transcriptional antiterminator, BglG family
licT
Beta-glucoside bgl operon transcriptional antiterminator, BglG family

Position: -190
Score: 4.7
Sequence: ATAAAAGCGTTTTAAA
Locus tag: LBA1653
Name: pnuC
Funciton: NrdR-regulated deoxyribonucleotide transporter; Nicotinamide mononucleotide transporter
pnuC
NrdR-regulated deoxyribonucleotide transporter; Nicotinamide mononucleotide transporter

Position: -42
Score: 4.5
Sequence: ATAAAAGCGGATTCAT
Locus tag: LBA0452
Name: manL
Funciton: Mannose-specific PTS system, IIAB component (EC 2.7.1.69)
Locus tag: LBA0455
Name: manM
Funciton: Mannose-specific PTS system, IIC component (EC 2.7.1.69)
Locus tag: LBA0456
Name: manN
Funciton: Mannose-specific PTS system, IID component (EC 2.7.1.69)
Locus tag: LBA0457
Name: manO
Funciton: Predicted regulator of the mannose operon, ManO
manL
Mannose-specific PTS system, IIAB component (EC 2.7.1.69)
manM
Mannose-specific PTS system, IIC component (EC 2.7.1.69)
manN
Mannose-specific PTS system, IID component (EC 2.7.1.69)
manO
Predicted regulator of the mannose operon, ManO

Position: -58
Score: 4.3
Sequence: AAGAAAAGGGTTTCAT
Locus tag: LBA0745
Name: pmi
Funciton: Mannose-6-phosphate isomerase (EC 5.3.1.8)
pmi
Mannose-6-phosphate isomerase (EC 5.3.1.8)

Position: -169
Score: 4.7
Sequence: TATAAAGCGTTTTCAT
Position: -102
Score: 4.5
Sequence: TTGAAAGCGATCACAA
Locus tag: LBA1013
Name: treR
Funciton: Trehalose utilization transcriptional regulator TreR, GntR family
Locus tag: LBA1014
Name: treA
Funciton: Trehalose-6-phosphate hydrolase (EC 3.2.1.93)
treR
Trehalose utilization transcriptional regulator TreR, GntR family
treA
Trehalose-6-phosphate hydrolase (EC 3.2.1.93)

Position: -96
Score: 4.3
Sequence: TTGTGATCGCTTTCAA
Position: -29
Score: 4.8
Sequence: ATGAAAACGCTTTATA
Locus tag: LBA1012
Name: treP
Funciton: Trehalose-specific PTS system, EIIABC component (EC 2.7.1.69)
treP
Trehalose-specific PTS system, EIIABC component (EC 2.7.1.69)

Position: -37
Score: 4.2
Sequence: GAGAAAGCGAATACAA
Locus tag: LBA1779
Name: fruR
Funciton: Fructose utilization transcriptional regulator FruR, DeoR family
Locus tag: LBA1778
Name: fruB
Funciton: 1-phosphofructokinase (EC 2.7.1.56)
Locus tag: LBA1777
Name: fruA
Funciton: Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
fruR
Fructose utilization transcriptional regulator FruR, DeoR family
fruB
1-phosphofructokinase (EC 2.7.1.56)
fruA
Fructose-specific PTS system, IIABC component (EC 2.7.1.69)

Position: -44
Score: 4.9
Sequence: ATGCAAACGTTTTCAA
Locus tag: LBA0874
Name: bglA
Funciton: 6-phospho-beta-glucosidase (EC 3.2.1.86)
bglA
6-phospho-beta-glucosidase (EC 3.2.1.86)

Position: -206
Score: 5
Sequence: TTTTAAGCGCTTTCAT
Locus tag: LBA1443
Name: rafR
Funciton: Raffinose utilization transcriptional regulator RafR, AraC family
rafR
Raffinose utilization transcriptional regulator RafR, AraC family

Position: -131
Score: 5.1
Sequence: ATGAAAGCGTTATCAT
Locus tag: LBA1708
Name: licT
Funciton: Beta-glucoside bgl operon transcriptional antiterminator, BglG family
Locus tag: LBA1707
Name: bglP
Funciton: Beta-glucoside-specific PTS system, IIBCA component (EC 2.7.1.69)
Locus tag: LBA1706
Name: bglH
Funciton: 6-phospho-beta-glucosidase (EC 3.2.1.86)
licT
Beta-glucoside bgl operon transcriptional antiterminator, BglG family
bglP
Beta-glucoside-specific PTS system, IIBCA component (EC 2.7.1.69)
bglH
6-phospho-beta-glucosidase (EC 3.2.1.86)

Position: -100
Score: 4.5
Sequence: GTGAAAGCGAATACAT
Locus tag: LBA1689
Name: simA
Funciton: Maltose-6'-phosphate glucosidase (EC 3.2.1.122)
simA
Maltose-6'-phosphate glucosidase (EC 3.2.1.122)

Position: -134
Score: 4.2
Sequence: ATGTAAGTGCTAACAT
Locus tag: LBA0956
Name: pfk
Funciton: 6-phosphofructokinase (EC 2.7.1.11)
Locus tag: LBA0957
Name: pyk
Funciton: Pyruvate kinase (EC 2.7.1.40)
pfk
6-phosphofructokinase (EC 2.7.1.11)
pyk
Pyruvate kinase (EC 2.7.1.40)

Position: -138
Score: 4.7
Sequence: TTGCAATCGCTTACAT
Locus tag: LBA1479
Name: glcT
Funciton: Beta-glucoside bgl operon antiterminator, BglG family
Locus tag: LBA1478
Name: glclP
Funciton: Beta-glucosides PTS, EIIBCA (EC 2.7.1.69)
glcT
Beta-glucoside bgl operon antiterminator, BglG family
glclP
Beta-glucosides PTS, EIIBCA (EC 2.7.1.69)

Position: -161
Score: 4.3
Sequence: AAGCAAGCGCTTCCAT
Locus tag: LBA0461
Name: adhE
Funciton: Alcohol dehydrogenase (EC 1.1.1.1); Acetaldehyde dehydrogenase (EC 1.2.1.10)
adhE
Alcohol dehydrogenase (EC 1.1.1.1); Acetaldehyde dehydrogenase (EC 1.2.1.10)

Position: -66
Score: 4.7
Sequence: TTGTAAACGCTTTATA
Locus tag: LBA1632
Name: gabD
Funciton: Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16)
gabD
Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16)

Position: -74
Score: 4.4
Sequence: TGTAAACCGCTTTCAA
Position: -48
Score: 4.6
Sequence: ATGAAAGCGTAAACAA
Locus tag: LBA1870
Name: mapA
Funciton: Maltose phosphorylase (EC 2.4.1.8) / Trehalose phosphorylase (EC 2.4.1.64)
Locus tag: LBA1869
Name: pgmB
Funciton: Beta-phosphoglucomutase (EC 5.4.2.6)
mapA
Maltose phosphorylase (EC 2.4.1.8) / Trehalose phosphorylase (EC 2.4.1.64)
pgmB
Beta-phosphoglucomutase (EC 5.4.2.6)

Position: -85
Score: 4.6
Sequence: TTGCAAACGTTTACAG
Locus tag: LBA0430
Name: pepQ
Funciton: Xaa-Pro dipeptidase (EC 3.4.13.9)
pepQ
Xaa-Pro dipeptidase (EC 3.4.13.9)

Position: -111
Score: 4.4
Sequence: ATGTAAACTGTTACAT
Locus tag: LBA0639
Name: ptsH
Funciton: Phosphotransferase system, HPr-related protein
Locus tag: LBA0640
Name: ptsI
Funciton: Phosphoenolpyruvate-protein kinase, PTS system component (EC 2.7.3.9)
ptsH
Phosphotransferase system, HPr-related protein
ptsI
Phosphoenolpyruvate-protein kinase, PTS system component (EC 2.7.3.9)

Position: -220
Score: 4.9
Sequence: ATGTAAACGCTTTTAT
Position: -188
Score: 4.5
Sequence: ATGATAACGTATTCAA
Position: -31
Score: 4.6
Sequence: AAGATAACGCTTACAT
Locus tag: LBA0400
Name: scrB
Funciton: Sucrose-6-phosphate hydrolase (EC 3.2.1.26)
Locus tag: LBA0399
Name: scrR
Funciton: Sucrose operon repressor ScrR, LacI family
scrB
Sucrose-6-phosphate hydrolase (EC 3.2.1.26)
scrR
Sucrose operon repressor ScrR, LacI family

Position: -54
Score: 4.6
Sequence: TTGCAACCGATTTCAT
Locus tag: LBA0225
Name: bglA
Funciton: 6-phospho-beta-glucosidase (EC 3.2.1.86)
bglA
6-phospho-beta-glucosidase (EC 3.2.1.86)

Position: -72
Score: 4.4
Sequence: ATGAAAGCGCTATACT
Locus tag: LBA1873
Name: ackB
Funciton: Acetate kinase (EC 2.7.2.1)
ackB
Acetate kinase (EC 2.7.2.1)

Position: -219
Score: 4.7
Sequence: ATGTAAGCGTTATCTT
Position: -30
Score: 4.9
Sequence: ATAAAAGCGTTTACAT
Locus tag: LBA0401
Name: scrA
Funciton: Sucrose-specific PTS system, IIABC component (EC 2.7.1.69)
scrA
Sucrose-specific PTS system, IIABC component (EC 2.7.1.69)

Position: -47
Score: 5
Sequence: ATAAAAGCGTTTTCAA
Locus tag: LBA1467
Name: lacL
Funciton: Beta-galactosidase large subunit (EC 3.2.1.23)
Locus tag: LBA1468
Name: lacM
Funciton: Beta-galactosidase small subunit (EC 3.2.1.23)
lacL
Beta-galactosidase large subunit (EC 3.2.1.23)
lacM
Beta-galactosidase small subunit (EC 3.2.1.23)

Position: -40
Score: 4.8
Sequence: TTGAAAGCGAATACAT
Locus tag: LBA1812
Name: agl3
Funciton: Alpha-glucosidase (EC 3.2.1.20)
agl3
Alpha-glucosidase (EC 3.2.1.20)

Position: -90
Score: 4.3
Sequence: GTGAATGCGCTTATAA
Locus tag: LBA0752
Name: pgi
Funciton: Glucose-6-phosphate isomerase (EC 5.3.1.9)
pgi
Glucose-6-phosphate isomerase (EC 5.3.1.9)

Position: -36
Score: 4.3
Sequence: CTGAAAACGATTACAG
Locus tag: LBA1459
Name: galK
Funciton: Galactokinase (EC 2.7.1.6)
Locus tag: LBA1458
Name: galT
Funciton: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
Locus tag: LBA1457
Name: galM
Funciton: Aldose 1-epimerase (EC 5.1.3.3)
galK
Galactokinase (EC 2.7.1.6)
galT
Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
galM
Aldose 1-epimerase (EC 5.1.3.3)

Position: -55
Score: 4.3
Sequence: AAGTAAGCGCTTTCCG
Locus tag: LBA0680
Name: glgB
Funciton: 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18)
Locus tag: LBA0681
Name: glgC
Funciton: Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27)
Locus tag: LBA0682
Name: glgD
Funciton: Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27)
Locus tag: LBA0683
Name: glgA
Funciton: Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21)
Locus tag: LBA0685
Name: glgP
Funciton: Glycogen phosphorylase (EC 2.4.1.1)
Locus tag: LBA0686
Name: amy1
Funciton: Neopullulanase (EC 3.2.1.135)
glgB
1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18)
glgC
Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27)
glgD
Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27)
glgA
Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21)
glgP
Glycogen phosphorylase (EC 2.4.1.1)
amy1
Neopullulanase (EC 3.2.1.135)

Position: -35
Score: 4.7
Sequence: TTGTAAGCGATTGCAT
Locus tag: LBA1433
Name: dhaK
Funciton: Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), dihydroxyacetone binding subunit DhaK
Locus tag: LBA1434
Name: dhaL
Funciton: Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), ADP-binding subunit DhaL
Locus tag: LBA1435
Name: dhaM
Funciton: Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), subunit DhaM; DHA-specific IIA component
Locus tag: LBA1436
Name: glpF2
Funciton: Glycerol uptake facilitator protein
dhaK
Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), dihydroxyacetone binding subunit DhaK
dhaL
Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), ADP-binding subunit DhaL
dhaM
Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), subunit DhaM; DHA-specific IIA component
glpF2
Glycerol uptake facilitator protein

Position: -35
Score: 4.8
Sequence: ATGAAAGCGATTACAG
Locus tag: LBA0885
Name: bglB
Funciton: Beta-glucosidase (EC 3.2.1.21); 6-phospho-beta-glucosidase (EC 3.2.1.86)
Locus tag: LBA0884
Name: LBA0884
Funciton: PTS system, IIC component
bglB
Beta-glucosidase (EC 3.2.1.21); 6-phospho-beta-glucosidase (EC 3.2.1.86)
LBA0884
PTS system, IIC component

Position: -52
Score: 4.4
Sequence: ATGAAAGAGGTTACAA
Locus tag: LBA1401
Name: hcaD
Funciton: NADH peroxidase (EC 1.11.1.1)
hcaD
NADH peroxidase (EC 1.11.1.1)
Export
Regulated Genes [ Tab delimited format ] DOWNLOAD
Regulatory Sites [ FASTA format ] DOWNLOAD