Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog SaeR - Staphylococcaceae

Properties
Regulator type: Transcription factor
Regulator family: OmpR
Regulation mode: activator
Biological process: Virulence
Effector: SaeS, sensor histidine kinase
Phylum: Firmicutes
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 45 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Staphylococcus aureus subsp. aureus N315 32 22
Staphylococcus capitis SK14 6 3
Staphylococcus epidermidis ATCC 12228 6 3
Staphylococcus carnosus subsp. carnosus TM300 7 2
Staphylococcus haemolyticus JCSC1435
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
Macrococcus caseolyticus JCSC5402
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
tst
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -110
score = 5.19121
sequence = ATTAATATATATTTAA

Gene: SA1819: toxic shock syndrome toxin-1
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
toxic shock syndrome toxin-1
 
CRON 2.
splA
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -121
score = 5.58116
sequence = TTTAATAAAATGTTAA

Site:
position = -99
score = 5.63725
sequence = GTTAATTAATATTTAA

Gene: SA1631: serine protease SplA
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
serine protease SplA
 
CRON 3.
set15
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -123
score = 5.31469
sequence = ATTAATTTTTAGTTAA

Gene: SA0393: superantigen-like protein
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
superantigen-like protein
SA0394
 
Staphylococcus aureus subsp. aureus N315

Gene: SA0394: hypothetical protein
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
hypothetical protein
 
CRON 4.
set13
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -175
score = 5.24488
sequence = ATTAAAAATCAGTTAA

Gene: SA0389: superantigen-like protein
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
superantigen-like protein
 
CRON 5.
set11
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -145
score = 5.16731
sequence = GTTCAAAAATAGTTAA

Site:
position = -134
score = 4.88005
sequence = GTTAAAAAGAGGTTAA

Gene: SA0387: superantigen-like protein
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
superantigen-like protein
 
CRON 6.
SE2396
 
Staphylococcus aureus subsp. aureus N315
*
Staphylococcus capitis SK14

Site:
position = -65
score = 4.95339
sequence = GTTAATTGTTACTTAA

Site:
position = -87
score = 5.3838
sequence = GTTAATAAAATTTTAA

Gene: STACA0001_1401: major facilitator family transporter
*
Staphylococcus epidermidis ATCC 12228

Site:
position = -288
score = 5.13475
sequence = TTTAATAATAAATTAA

Site:
position = -65
score = 5.26697
sequence = ATTAATAATTTTTTAA

Gene: SE2396: transporter
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
major facilitator family transporter
 
CRON 7.
Sca_1510
 
Staphylococcus aureus subsp. aureus N315
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -50
score = 4.94834
sequence = ATTAATATTCTGTTAA

Gene: Sca_1510: hypothetical protein
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
hypothetical protein
sbi
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -92
score = 6.05334
sequence = GTTAATAATTAGTTAA

Gene: SA2206: IgG-binding protein SBI
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_1511: IgG-binding protein SBI
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
IgG-binding protein SBI
 
CRON 8.
sak
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -175
score = 5.45869
sequence = GTTAAATATTTGTTAA

Site:
position = -164
score = 5.3996
sequence = GTTAATTATTTTTTAA

Gene: SA1758: staphylokinase
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
staphylokinase
 
CRON 9.
saeP
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -99
score = 5.02694
sequence = GTTAAGCGATATTTAA

Site:
position = -78
score = 5.86932
sequence = GTTAAGAATTAGTTAA

Gene: SA0663: hypothetical protein SaeP
*
Staphylococcus capitis SK14

Site:
position = -79
score = 5.89123
sequence = GTTAATAAAAAGTTAA

Site:
position = -100
score = 4.99187
sequence = TTTAATTCTTTTTTAA

Gene: STACA0001_0321: hypothetical protein SaeP
*
Staphylococcus epidermidis ATCC 12228

Site:
position = -79
score = 5.89123
sequence = GTTAAGAAATAGTTAA

Site:
position = -100
score = 4.99187
sequence = TTTAATTCTTTTTTAA

Gene: SE0481: hypothetical protein SaeP
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -88
score = 5.79631
sequence = ATTAATAAATAGTTAA

Gene: Sca_0350: hypothetical protein SaeP
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
hypothetical protein SaeP
saeQ
 
Staphylococcus aureus subsp. aureus N315

Gene: SA0662: hypothetical protein SaeQ
 
Staphylococcus capitis SK14

Gene: STACA0001_0322: hypothetical protein SaeQ
 
Staphylococcus epidermidis ATCC 12228

Gene: SE0480: hypothetical protein SaeQ
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_0351: hypothetical protein SaeQ
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
hypothetical protein SaeQ
saeR
 
Staphylococcus aureus subsp. aureus N315

Gene: SA0661: response regulator SaeR
 
Staphylococcus capitis SK14

Gene: STACA0001_0323: response regulator SaeR
 
Staphylococcus epidermidis ATCC 12228
 2
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_0352a: response regulator SaeR

Gene: Sca_0352: response regulator SaeR
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
response regulator SaeR
saeS
 
Staphylococcus aureus subsp. aureus N315

Gene: SA0660: histidine protein kinase SaeS
 
Staphylococcus capitis SK14

Gene: STACA0001_0324: histidine protein kinase SaeS
 
Staphylococcus epidermidis ATCC 12228

Gene: SE0478: histidine protein kinase SaeS
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_0353: histidine protein kinase SaeS
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
histidine protein kinase SaeS
saeR
 
Staphylococcus aureus subsp. aureus N315
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228

Gene: SE0479: response regulator SaeR
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
response regulator SaeR
 
CRON 10.
SA1818
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -98
score = 4.7376
sequence = TTTATGTATTTGTTAA

Site:
position = -87
score = 5.76165
sequence = GTTAATAATTATTTAA

Gene: SA1818: lipoprotein involved in pathogenicity
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
lipoprotein involved in pathogenicity
 
CRON 11.
SA1754
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -77
score = 5.24012
sequence = GTTAATGAATAATTAA

Gene: SA1754: hypothetical protein
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
hypothetical protein
 
CRON 12.
SA1633
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -86
score = 4.97027
sequence = TTTGATATTTAGTTAA

Site:
position = -97
score = 4.57908
sequence = GTTAATACATTTTTGA

Site:
position = -108
score = 5.76185
sequence = GTTAATAGATAGTTAA

Gene: SA1633: beta-lactamase
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
beta-lactamase
 
CRON 13.
SA1000
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -99
score = 5.2661
sequence = ATTAATGTTTAGTTAA

Site:
position = -88
score = 6.07525
sequence = GTTAATAAATAGTTAA

Gene: SA1000: similar to fibrinogen binding protein
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
similar to fibrinogen binding protein
 
CRON 14.
SA0357
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -95
score = 5.42376
sequence = GTTAATCAAGAGTTAA

Gene: SA0357: hypothetical protein similar to exotoxin 2
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
hypothetical protein similar to exotoxin 2
 
CRON 15.
SA0213
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -100
score = 5.79631
sequence = ATTAATAAATAGTTAA

Gene: SA0213: putative membrane protein
*
Staphylococcus capitis SK14

Site:
position = -99
score = 5.79631
sequence = ATTAATAAATAGTTAA

Gene: STACA0001_0021: putative membrane protein
*
Staphylococcus epidermidis ATCC 12228

Site:
position = -99
score = 6.07525
sequence = GTTAATAAATAGTTAA

Gene: SE0163: putative membrane protein
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_0082: putative membrane protein
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
putative membrane protein
 
CRON 16.
map
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -88
score = 5.16408
sequence = ATTAATATTCAGTTAA

Gene: SA1751: MHC class II analog protein
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
MHC class II analog protein
map
 
Staphylococcus aureus subsp. aureus N315

Gene: SA1750: MHC class II analog protein
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
MHC class II analog protein
 
CRON 17.
lukS
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -99
score = 5.98092
sequence = TTTAATAAATAGTTAA

Gene: SA1813: leukocidin lukS
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
leukocidin lukS
lukF
 
Staphylococcus aureus subsp. aureus N315

Gene: SA1812: leukocidin lukF
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
leukocidin lukF
 
CRON 18.
lukE
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -86
score = 5.48911
sequence = TTTAATGAACAGTTAA

Site:
position = -335
score = 5.75643
sequence = GTTAATAATCAGTTAA

Gene: SA1638: leukotoxin LukE
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
leukotoxin LukE
lukD
 
Staphylococcus aureus subsp. aureus N315

Gene: SA1637: leukotoxin, LukD
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
leukotoxin, LukD
 
CRON 19.
lpl2
*2
Staphylococcus aureus subsp. aureus N315

Gene: SA0397: lipoprotein involved in pathogenicity

Site:
position = -253
score = 5.98092
sequence = TTTAATAAATAGTTAA

Gene: SA0396: lipoprotein involved in pathogenicity
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
lipoprotein involved in pathogenicity
lpl3
 
Staphylococcus aureus subsp. aureus N315

Gene: SA0398: lipoprotein involved in pathogenicity
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
lipoprotein involved in pathogenicity
 
CRON 20.
hlgC
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -86
score = 5.58345
sequence = GTTAATGAACAGTTAA

Gene: SA2208: gamma-hemolysin component C
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
gamma-hemolysin component C
hlgB
 
Staphylococcus aureus subsp. aureus N315

Gene: SA2209: gamma-hemolysin component B
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
gamma-hemolysin component B
 
CRON 21.
hla
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -190
score = 5.41799
sequence = TTTAAATAAAAGTTAA

Gene: SA1007: alpha-hemolysin
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
alpha-hemolysin
 
CRON 22.
SA1003
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -81
score = 5.7744
sequence = ATTAATAATTAGTTAA

Site:
position = -85
score = 4.61336
sequence = GTTAATTAATAATTAG

Gene: efb: similar to fibrinogen binding protein
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
similar to fibrinogen binding protein
 
CRON 23.
coa
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -82
score = 5.76185
sequence = GTTAATATATAGTTAA

Site:
position = -103
score = 4.65397
sequence = GTTAATGCTTTGTTTA

Gene: SA0222: staphylocoagulase precursor
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
staphylocoagulase precursor
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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